PACAP (1-38) (human, mouse, ovine, porcine, rat) (trifluoroacetate salt) (Synonyms: Pituitary Adenylate Cyclase-activating Peptide (1-38)) |
| カタログ番号GC44532 |
下垂体アデニル酸シクラーゼ活性化ペプチド（PACAP）（1-38）は、CHO細胞で発現したラットPAC1、ラットVPAC1、およびヒトVPAC2再構成受容体に対してそれぞれIC50値が4、2、および1 nMのPACAP受容体作動薬です。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Pituitary adenylate cyclase-activating peptide (PACAP) (1-38) is a PACAP receptor agonist with IC50 values of 4, 2, and 1 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors in rat brain membrane (IC50 = 4.45 nM) and to SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 3.6, 13, and 4.7 nM, respectively). It also stimulates cAMP accumulation in H-SY5Y, SK-N-MC, and T47D cells (EC50s = 0.37, 0.26, and 0.73 nM, respectively). In vivo, in newborn pigs, PACAP (1-38) (1 μM) induces vasodilation of pial arterioles by 43%.
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