SN-38 Glucuronide (trifluoroacetate salt) (Synonyms: SN-38G) |
| カタログ番号GC44906 |
SN-38グルクロン酸は、カンプトテシンアルカロイドの誘導体であるイリノテカンの不活性代謝物です。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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SN-38 glucuronide is an inactive metabolite of irinotecan , which is a derivative of the alkaloid camptothecin. [1] SN-38 glucuronide is formed by glucuronidation of SN-38 , the active metabolite of irinotecan, by UDP glucuronosyl transferase 1A1 (UGT1A1) and UGT1A7. It can also be formed in COS-7 cells by UGT1A1 and UGT1A10, which are both up-regulated in an irinotecan/SN-38-resistant cell line. [2]
Reference:
[1]. Mathijssen, R.H.J., van Alphen, R.J., Verweij, J., et al. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). Clin. Cancer Res. 7(8), 2182-2194 (2001).
[2]. Oguri, T., Takahashi, T., Miyazaki, M., et al. UGT1A10 is responsible for SN-38 glucuronidation and its expression in human lung cancers. Anticancer Res. 24(5A), 2893-2896 (2004).
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