YW3-56 (hydrochloride) |
| カタログ番号GC45176 |
YW3-56は、タンパク質アルギニンディミナーゼ2（PAD2）およびPAD4の阻害剤であり（それぞれIC50 = 0.5〜1および1〜5μM）、
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively). It inhibits the growth of U2OS osteosarcoma cells (IC50 = ~2.5 μM) in a p53-dependent manner via induction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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