CAY10575 (Synonyms: IKK2 Inhibitor 3, Polo-like Kinase Inhibitor 1) |
| カタログ番号GC43176 |
CAY10575 (化合物 8) は、IC50 が 0.075 μM の IKK2 阻害剤です。
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Cas No.: 916985-21-2
Sample solution is provided at 25 µL, 10mM.
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The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKK-α and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells and is thought to play a role in the immune response. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC50 value of ~15.8 µM.
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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