Cibenzoline |
| カタログ番号GC64925 |
シベンゾリンは、SUR1 サブユニットではなく細孔形成 Kir6.2 サブユニットに直接影響を与える KATP チャネルの強力な阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53267-01-9
Sample solution is provided at 25 µL, 10mM.
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Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic drug. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy[1][2].
[1]. Mukai E, et al. The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998;251(2):477-481.
[2]. Hamada M, et al. Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy. Circulation. 1997;96(5):1520-1524.
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