Cidofovir dihydrate |
カタログ番号GC13936 |
シドフォビル (GS 0504; HPMPC; (S)-HPMPC) 二水和物は、非環式一リン酸ヌクレオチド類似体であり、抗ウイルス活性を持つ CMV 阻害剤です。
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Cas No.: 149394-66-1
Sample solution is provided at 25 µL, 10mM.
Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis.Target: CMV DNA polymeraseCidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is an acyclic nucleoside phosphonate, and is therefore independent of phosphorylation by viral enzymes, unlike acyclovir.Cidofovir was discovered at the Institute of Organic Chemistry and Biochemistry, Prague, by Antonín Hol , and developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the USA, and by Pfizer elsewhere. Maintenance therapy with cidofovir involves an infusion only once every two weeks, making it a convenient treatment option. Because dosing is relatively infrequent, a permanent catheter is not necessary for infusions.
References:
[1]. Becker MN, et al. Isolation and characterization of cidofovir resistant vaccinia viruses. Virol J. 2008 May 14;5:58.
[2]. Kazory A, et al. Simultaneous development of Fanconi syndrome and acute renal failure associated with cidofovir. J Antimicrob Chemother. 2007 Jul;60(1):193-4. Epub 2007 May 11.
[3]. Segarra-Newnham M, et al. Use of cidofovir in progressive multifocal leukoencephalopathy. Ann Pharmacother. 2001 Jun;35(6):741-4.
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