(Z)-4EGI-1 |
| カタログ番号GC39842 |
(Z)-4EGI-1 は 4EGI-1 の Z 異性体であり、eIF4E/eIF4G 相互作用および翻訳開始の阻害剤です。 (Z)-4EGI-1 は、43.5 μM の IC50 および 8.74 μM の Kd 値で効果的に eIF4E に結合します。 (Z)-4EGI-1 には抗がん作用があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 901787-88-0
Sample solution is provided at 25 µL, 10mM.
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(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2].
[1]. Khuloud Takrouri, et al. Structure-activity Relationship Study of 4EGI-1, Small Molecule eIF4E/eIF4G Protein-Protein Interaction Inhibitors. Eur J Med Chem. 2014 Apr 22;77:361-77. [2]. Poornachandran Mahalingam, et al. Synthesis of Rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein-Protein Interaction. J Med Chem. 2014 Jun 26;57(12):5094-111.
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