Ciprostene (calcium salt) (Synonyms: Ciprostene calcium, U61431F) |
| カタログ番号GC43270 |
シプロステンは、カルバプロスタサイクリンの9β-メチルアナログであり、PGI2の安定したアナログです。
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Cas No.: 81703-55-1
Sample solution is provided at 25 µL, 10mM.
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Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 µg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 µg/kg/min and 60 ng/ml, respectively.
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