Clavulanate (potassium salt) (Synonyms: BRL 14151K) |
カタログ番号GC15637
One-Click Copy Product Info
|
β-ラクタマーゼ阻害剤
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 61177-45-5
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
Clavulanate is a metabolite existed in cultures of Streptomyces clavuligerusa with activity against both Gram-positive and Gram-negative bacteria. Clavulanate is a first clinically useful broad-spectrum β-lactamase inhibitor. Clavulanate formulations have been widely used in the treatment of a broad range of clinical infections [1].
Clavulanate was least active against Pseudomonas spp. and the enterococci with MICs of 125–512 mg/L, followed by members of the Enterobacteriaceae and H. influenzae with MICs of 12–125 mg/L. Clavulanate showed great activity against Bacteroides spp. and other anaerobes, M. catarrhalis, staphylococci and streptococci with MICs of 4–50 mg/L. Clavulanate was active against Neisseria spp. with MICs of 1.25–4 mg/L [1].
In an infection model of L. pneumophila pneumonia leucopenic weanling rats, clavulanate effectively prevented the development of infection. In a mouse lethal thigh infection model with two susceptible strains of S. pneumoniae, treatment with clavulanate decreased the mortality [1].
Reference:
[1] Finlay J, Miller L, Poupard J A. A review of the antimicrobial activity of clavulanate[J]. Journal of Antimicrobial Chemotherapy, 2003, 52(1): 18-23.
| Cas No. | 61177-45-5 | SDF | |
| 同義語 | BRL 14151K | ||
| Chemical Name | (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monopotassium salt | ||
| Canonical SMILES | O=C1C[C@]2([H])N1[C@@H](C([O-])=O)/C(O2)=C/CO.[K+] | ||
| Formula | C8H8NO5 • K | M.Wt | 237.3 |
| 溶解度 | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.2141 mL | 21.0704 mL | 42.1408 mL |
| 5 mM | 842.8 μL | 4.2141 mL | 8.4282 mL |
| 10 mM | 421.4 μL | 2.107 mL | 4.2141 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)