CS-2660 (JNJ-38158471) |
カタログ番号GC25313
One-Click Copy Product Info
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CS-2660（JNJ-38158471）は、IC50が40 nMの高度に選択的なVEGFR-2阻害剤であり、経口摂取可能でよく耐容性があります。 CS-2660（JNJ-38158471）はまた、RET（c-RET）やKit（c-Kit）などの密接に関連するチロシンキナーゼを180 nMおよび500 nMのIC50で阻害しますが、VEGFR-1およびVEGFR -3に対して有意な活性を示しません（> 1マイクロM）。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 951151-97-6
Sample solution is provided at 25 µL, 10mM.
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CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as RET (c-RET) and Kit (c-Kit) with IC50 of 180 nM and 500 nM，while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.
[1] Kenneth R LaMontagne, et al. Angiogenesis. 2009;12(3):287-96.
| Cas No. | 951151-97-6 | SDF | |
| Formula | C15H17ClN6O3 | M.Wt | 364.79 |
| 溶解度 | DMSO: 30 mg/mL (82.24 mM);Water: Insoluble;Ethanol: Insoluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7413 mL | 13.7065 mL | 27.413 mL |
| 5 mM | 548.3 μL | 2.7413 mL | 5.4826 mL |
| 10 mM | 274.1 μL | 1.3707 mL | 2.7413 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)