VU0650786 |
| カタログ番号GC34859 |
VU0650786 は、代謝型グルタミン酸受容体サブタイプ 3 (mGlu3 NAM) の強力かつ選択的な CNS 浸透性ネガティブ アロステリック モジュレーターであり、IC50 は 392 nM です。
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Cas No.: 1809085-30-0
Sample solution is provided at 25 µL, 10mM.
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VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1]. mGluR3|392 nM (IC50)
[1]. Engers JL, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58(18):7485-500.
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