D-Fructose-13C6 (Synonyms: D-(–)-Fructose-13C6, D-(–)-Levulose-13C6)

D-Fructose-¹³C₆ is intended for use as an internal standard for the quantification of D-fructose by GC- or LC-MS. D-Fructose is a ubiquitous monosaccharide and is derived, in addition to glucose, from the breakdown of sucrose by sucrase in the intestine.¹ It is a precursor in the biosynthesis of D-fructose-1,6-bisphosphate , which is an intermediate in the production of D-glucose via gluconeogenesis. Deficiencies in the enzymes that metabolize D-fructose are inborn errors of metabolism that range from benign, for fructokinase deficiency, to severe, for hereditary fructose intolerance, if D-fructose, sucrose, and sorbitol are not eliminated from the diet.² Increased consumption of D-fructose is associated with obesity, dyslipidemia, and impaired insulin sensitivity.³

1.Chen, M., and Whistler, R.L.Metabolism of D-fructoseAdv. Carbohydr. Chem. Biochem.34265-343(1977) 2.Tran, C.Inborn errors of fructose metabolism. What can we learn from them•Nutrients9(4)E356(2017) 3.Tappy, L., and Lě, K.-A.Metabolic effects of fructose and the worldwide increase in obesityPhysiol. Rev.90(1)23-46(2010)