D77 |
| カタログ番号GC33982 |
D77 は、インテグラーゼと細胞の LEDGF/p75 との相互作用を標的とする抗 HIV-1 阻害剤です。 D77 は、MT-4 細胞で EC50 値 23.8 μg/ml (C8166 細胞では 5.03 μg/ml) で HIV-1(IIIB) 複製を阻害します。
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Cas No.: 497836-10-9
Sample solution is provided at 25 µL, 10mM.
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D77 is anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells).IC50 value: 23.8 μg/ml (EC50, in MT-4 cell ), 5.03 μg/ml (EC50, in C8166 cell)Target: HIV-1in vitro: D77 exhibits a highly specific binding affinity to HIV-1 integrase catalytic core domain.D77 induces a dramatic concentration-dependent decrease of α-galactosidase activity compared to the D77-untreated cells. D77 reveals a significant inhibition activity against the interaction of IN with IBD.
[1]. Du L, et al. D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. Biochem Biophys Res Commun. 2008 Oct 10;375(1):139-144.
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