Dexchlorpheniramine (maleate) (Synonyms: d-Chlorpheniramine (maleate)) |
| カタログ番号GC43427 |
デクスクロルフェニラミン (マレイン酸塩) は抗ヒスタミン薬であり、抗コリン作用があり、アレルギー状態の治療に使用されます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2438-32-6
Sample solution is provided at 25 µL, 10mM.
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Dexchlorpheniramine is a histamine H1 receptor antagonist with a pA2 value of 9.36 in guinea pig ileal tissue in vitro. [1] It inhibits the proliferation of previously sensitized, allergen-challenged peripheral blood mononuclear cells by 92% at a concentration of 4.8 µM. [2] Dexchlorpheniramine reduces noradrenaline uptake in the rat vas deferens ex vivo in response to tyramine stimulation when used at a concentration of 10 µM.[3] In vivo, dexchlorpheniramine increases the pain threshold of mice exposed to thermal and chemical stimulation tests when administered intraperitoneally at a dose of 30 mg/kg.[4] Formulations containing dexchlorpheniramine have been used for the treatment of allergic reactions.
Reference:
[1]. Shamsa, F., Ahmadiani, A., and Khosrokhavar, R. Antihistaminic and anticholinergic activity of barberry fruit (Berberis vulgaris) in the guinea-pig ileum. J. Ethnopharmacol. 64(2), 161-166 (1999).
[2]. Holen, E., Elsayed, S., and Nyfors, A. The effect of H1 receptor antagonists on peripheral blood mononuclear cells, adenoid cells and primary cell lines. APMIS 103(2), 98-106 (1995).
[3]. Barnett, A., Symchowicz, S., and Taber, R.I. The effects of drugs inhibiting catecholamine uptake on tyramine and noradrenaline-induced contractions of the isolated rat vas deferens. Br. J. Pharmacol. 34(3), 484-492 (1968).
[4]. Farzin, D., Asghari, L., and Nowrouzi, M. Rodent antinociception following acute treatment with different histamine receptor agonists and antagonists. Pharmacol. Biochem. Behav. 72(3), 751-760 (2002).
| Cas No. | 2438-32-6 | SDF | |
| 同義語 | d-Chlorpheniramine (maleate) | ||
| Chemical Name | γS-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine, 2Z-butenedioate | ||
| Canonical SMILES | ClC(C=C1)=CC=C1[C@H](CCN(C)C)C2=CC=CC=N2.OC(/C=C\C(O)=O)=O | ||
| Formula | C16H19ClN2•C4H4O4 | M.Wt | 390.9 |
| 溶解度 | DMSO : ≥ 100 mg/mL (255.85 mM); H2O : ≥ 100 mg/mL (255.85 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5582 mL | 12.791 mL | 25.582 mL |
| 5 mM | 0.5116 mL | 2.5582 mL | 5.1164 mL |
| 10 mM | 0.2558 mL | 1.2791 mL | 2.5582 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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