Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (Synonyms: DDC, 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine, NSC 8910, NSC 49528) |
| カタログ番号GC40666 |
ジエチル1,4-ジヒドロ-2,4,6-トリメチル-3,5-ピリジンジカルボキシレート（DDC）は、フェロケラターゼを阻害することによってヘムの生成を抑制します。フェロケラターゼは、プロトポルフィリンIXにFe2+を付加してヘムBを作る酵素です。
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Cas No.: 632-93-9
Sample solution is provided at 25 µL, 10mM.
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Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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