E3 ligase Ligand-Linker Conjugates 12 (Synonyms: VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12) |
カタログ番号GC33000 |
E3 リガーゼ リガンド-リンカー コンジュゲート 12 は、PROTAC テクノロジーで使用される (S,R,S)-AHPC ベースの VHL リガンドと 3 ユニット PEG リンカーを組み込んだ合成 E3 リガーゼ リガンド-リンカー コンジュゲートです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1797406-80-4
Sample solution is provided at 25 µL, 10mM.
E3 ligase Ligand-Linker Conjugates 12 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
E3 ligase Ligand-Linker Conjugates 12 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker[1][2].
[1]. WO/2016/146985A1 [2]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.
Average Rating: 5
(Based on Reviews and 12 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *