EMI48 |
| カタログ番号GC60805 |
EMI1 の誘導体である EMI48 は、EMI1 よりも変異体 EGFR に対してより大きな効力を示します。 EMI48 は EGFR 三重変異体を阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 34564-13-1
Sample solution is provided at 25 µL, 10mM.
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EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants[1].
EMI48 inhibits EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S. EMI48 can be used in the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].
[1]. Punit Saraon , et al. A Drug Discovery Platform to Identify Compounds That Inhibit EGFR Triple Mutants.Nat Chem Biol. 2020 May;16(5):577-586.
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