ERK5-IN-1 (Synonyms: ERK5-IN-1) |
| カタログ番号GC32796 |
ERK5-IN-1 は、87±7 nM の IC50 を持つ強力な ERK5 阻害剤です。 ERK5-IN-1 は LRRK2[G2019S] も 26 nM の IC50 で阻害します。
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Cas No.: 1234479-76-5
Sample solution is provided at 25 µL, 10mM.
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ERK5-IN-1 is a potent ERK5 inhibitor with an IC50 of 87±7 nM. ERK5-IN-1 also inhibits LRRK2[G2019S] with an IC50 of 26 nM.
ERK5-IN-1 (Compound 5) exhibits a cellular EC50 for inhibiting epidermal growth factor (EGF) induced ERK5 autophosphorylation of 0.19±0.04 μM[1].
[1]. Deng X, et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. Eur J Med Chem. 2013;70:758-767.
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