Fascaplysin (chloride) (Synonyms: NSC 622398) |
| カタログ番号GC18693 |
Fascaplysin (chloride) は、海綿 (Fascaplysin (chloride)opsis sp.
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Cas No.: 114719-57-2
Sample solution is provided at 25 µL, 10mM.
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Fascaplysin is an inhibitor of cyclin D kinase 4/ cyclin D1 (IC50 = 0.35 μM) that was originally isolated from the marine sponge Thorectandra. It is significantly less selective for Cdk6/cyclin D1 (IC50 = 3.4 μM) and does not inhibit other Cdks and tyrosine kinases. Fascaplysin is reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest. Inhibition of Cdk4 via fascaplysin has been shown to induce peroxisome-proliferator-activated receptor γ-1α deacetylation (IC50 = 0.7 uM) and has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism.
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Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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