Furazolidone (Synonyms: Furoxone, NSC 6469, Nifulidone, Nitrofurazolidone, Nitrofuroxon, Tikofuran, Trifurox) |
| カタログ番号GC32138 |
フラゾリドンは、抗原虫および抗菌活性を有するニトロフラン誘導体であり、AML1-ETO 形質転換細胞を 12.7 μM の IC50 値で阻害します。
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Cas No.: 67-45-8
Sample solution is provided at 25 µL, 10mM.
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Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Target: Antibacterial Furazolidone is a novel therapeutic strategy in AML patients. Furazolidone can Inhibit the bone-marrow transformation mediated by a series of leukemia fusion proteins. Furazolidone significantly inhibits proliferation of AML cell lines. Furazolidone induces apoptosis of the AML leukemic cells treatment with Furazolidone induces differentiation of AML cell lines.
[1]. Jiang X, et al. A novel application of furazolidone: anti-leukemic activity in acute myeloid leukemia. PLoS One. 2013 Aug 9;8(8):e72335.
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