(Gln²²)-Amyloid β-Protein (1-40) |
カタログ番号GA20182 |
アミロイドβペプチドのオランダ変異体(E22Q)は、野生型ペプチドよりもより容易に凝集し、その結果得られるフィブリルは神経毒性が増加します。変異ペプチドE22Qは、濃度25μmで脳内皮細胞のアポトーシスを誘発しましたが、WT Aβ1-40およびイタリア変異体E22K(H-6698)には影響がありませんでした。
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Cas No.: 144410-00-4
Sample solution is provided at 25 µL, 10mM.
The Dutch mutation (E22Q) of amyloid β-peptide aggregates more readily than the wild-type peptide and the resulting fibrils show increased neurotoxicity. The mutant peptide E22Q induced apoptosis of cerebral endothelial cells at a concentration of
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