(±)-Medicarpin |
| カタログ番号GC34962 |
(±)-プテロカルパンであるメディカルピンは、ソフォラ ジャポニカ、ゾラーニア パラエンシス、プラティミシウム ユカタムン、マケリウム アリスチュラタム、プラティミシウム フロリバンダムなど、さまざまな生物学的効果を持ついくつかの薬用植物種から分離されたイソフラボノイドの一種です。 (±)-メディカルピンは、破骨細胞形成を強力に阻害し、骨治癒を促進し、エストロゲン受容体 (ER) β を介した骨形成作用による骨芽細胞の分化によって骨量を増加させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 33983-39-0
Sample solution is provided at 25 µL, 10mM.
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(±)-Medicarpin is a pterocarpan, a type of isoflavonoid. (±)-Medicarpin has been isolated from several medicinal plant species with various biological effects, including Sophora japonica as a phytoalexin, Zollernia paraensis and Platymiscium yucatamun with antifungal properties, Machaerium aristulatum, Platymiscium floribundum, and Brazilian red propolis with cytotoxic effects, and Dalbergia oliveri as a larvicidal compound. (±)-Medicarpin potently inhibits osteoclastogenesis and prevents estrogen-deficient bone loss but does not display uterine estrogenicity. It also promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action[1]. ERβ
[1]. Yang X, et al. Total Synthesis of (+)-Medicarpin. J Nat Prod. 2017 Dec 22;80(12):3284-3288.
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