CDK2-IN-4 |
| カタログ番号GC35632 |
CDK2-IN-4 は、CDK2/サイクリン A に対して 44 nM の IC50 を持つ強力かつ選択的な CDK2 阻害剤であり、CDK1/サイクリン B よりも 2,000 倍の選択性を示します (IC50 = 86 uM)。
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Cas No.: 2079895-42-2
Sample solution is provided at 25 µL, 10mM.
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CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM)[1]. cdk2/cyclin A|44 nM (IC50)|Cdk1/cyclin B|86 μM (IC50)
[1]. Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60(5):1746-1767.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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