Eupatorin (Synonyms: NSC 106402) |
| カタログ番号GC36017 |
天然に存在するフラボンであるユーパトリンは、細胞周期の G2-M 期で細胞を停止させ、複数のカスパーゼの活性化、シトクロム c のミトコンドリア放出、およびポリ (ADP-リボース) ポリメラーゼ切断を含むアポトーシス細胞死を誘導します。
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Cas No.: 855-96-9
Sample solution is provided at 25 µL, 10mM.
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Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage[1].
[1]. EstÉvez S, et al. Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway. PLoS One. 2014 Nov 12;9(11):e112536.
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