Filibuvir |
| カタログ番号GC36045 |
フィリブビルは、HCV 非構造 5B タンパク質 (NS5B) RNA 依存性 RNA ポリメラーゼ (RdRp) の経口的に活性な選択的非ヌクレオシド阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 877130-28-4
Sample solution is provided at 25 µL, 10mM.
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Filibuvir is a potent, selective non-nucleoside inhibitor (NNI) of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase, and it binds noncovalently in the "Thumb 2" pocket of NS5B. In vitro, filibuvir is equipotent against genotype 1a and 1b replicons, with an EC50 of 59 nM[1].
[1]. Wagner F, et al. Antiviral activity of the hepatitis C virus polymerase inhibitor filibuvir in genotype 1-infected patients. Hepatology. 2011 Jul;54(1):50-9.
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