Indirubin Derivative E804 |
| カタログ番号GC36311 |
Indirubin Derivative E804 は、インスリン様成長因子 1 受容体 (IGF1R) の強力な阻害剤であり、IGF1R の IC50 は 0.65 μM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 854171-35-0
Sample solution is provided at 25 µL, 10mM.
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E 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R. IC50: 0.65 μM (IGF1R)[1].
Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM[1].
[1]. Cheng X, et al. Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule. J Med Chem. 2017 Jun 22;60(12):4949-4962.
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