Liothyronine |
| カタログ番号GC36465 |
TRβ1に結合し、その活性を活性化する甲状腺ホルモン
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Cas No.: 6893/2/3
Sample solution is provided at 25 µL, 10mM.
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Liothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity. Human Endogenous Metabolite
Liothyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. Liothyronine promotes growth, induces differentiation and regualtes metabolic effects[2].
[1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.
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