MK-2894 sodium salt |
| カタログ番号GC36623 |
MK-2894 ナトリウム塩は、E プロスタノイド受容体 4 (EP4 受容体) (IC50=2.5 nM) に対する強力で選択的な経口活性の高親和性 (Ki=0.56 nM) の完全なアンタゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1006036-88-9
Sample solution is provided at 25 µL, 10mM.
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MK-2894 sodium salt is a highly potent and selective second generation EP4 antagonist.IC50 value:Target: EP4MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. MK-2894 also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.
[1]. Blouin M, Han Y, Burch J, Farand J, Mellon C, Gaudreault M, Wrona M, LÉvesque JF, Denis D, Mathieu MC, Stocco R, Vigneault E, Therien A, Clark P, Rowland S, Xu D, O'Neill G, Ducharme Y, Friesen R. The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluorometh
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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