TFMB-(R)-2-HG |
| カタログ番号GC38199 |
(R)-2-HG の細胞膜透過性バージョンである TFMB-(R)-2-HG は、急性骨髄性白血病 (AML) の発がん因子です。TFMB-(R)-2-HG は SCF ER を障害します。エストロゲン離脱に応答した Hoxb8 細胞の分化。
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Cas No.: 1445700-01-5
Sample solution is provided at 25 µL, 10mM.
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TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML).TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal[1].
[1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013 Mar 29;339(6127):1621-5.
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