Malic enzyme inhibitor ME1 (Synonyms: ME1) |
| カタログ番号GC38506 |
リンゴ酸酵素阻害剤 ME1 (ME1; 化合物 1) は、リンゴ酸酵素 (ME1) の強力な阻害剤であり、IC50 は 0.15 μM です。
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Cas No.: 522649-59-8
Sample solution is provided at 25 µL, 10mM.
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Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM[1][2].
Malic enzyme inhibitor ME1 (ME1; ME1*) (50 μM; 72 hours) shows a significant reduction in total cell numbers[2]. Malic enzyme inhibitor ME1 shows a significant reduction in cell viability/metabolic activity in MTS cell[2]. Malic enzyme inhibitor ME1 dose-dependently reduces the number of colonies formed by both HCT116 and HT29 cells[2]. Cell Viability Assay[2] Cell Line: HCT116 and HT29 cell line
[1]. Zhang YJ, et al. In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8. [2]. Fernandes L, et al. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 Sep 24;8(1):14268.
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