Hamaudol |
| カタログ番号GC38616 |
ハマドールはサポシュニコビア・ディバリカタから分離されたクロモンである。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 735-46-6
Sample solution is provided at 25 µL, 10mM.
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Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].
Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency[1].
[1]. Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001 Feb;49(2):154-60. [2]. Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13(2).
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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