Alkyne-PEG4-maleimide |
| カタログ番号GC59017 |
アルキン-PEG4-マレイミドは、PROTAC の合成に使用できる PEG ベースの PROTAC リンカーです。
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Cas No.: 1262681-30-0
Sample solution is provided at 25 µL, 10mM.
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When proteins or other sensitive biomolecules need to be conjugated, polyethyleneglycol (PEG) linkers are a great choice. They provide hydrophilicity and maintain separation between conjugated molecules. This linker based on PEG4, has length of 14Å (1.4 nm). Heterobifunctional linkers carrying different reactive groups can be used to prepare cross-conjugates between different molecules.
Maleimide functional group is especially useful, because they can label proteins site specifically. Most proteins have only limited number of cysteine residues that selectively react with maleimides. Alkyne group can be then conjugated with azides in a selective copper-catalyzed process, CuAAc (copper-catalyzed alkyne azide cycloaddition).
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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