1,7-Heptanediol |
カタログ番号GD14338
One-Click Copy Product Info
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1,7-Heptanediolは、E3ユビキチンリガーゼリガンドと標的タンパク質リガンドを連結するPROTACリンカーとして機能する。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 629-30-1
Sample solution is provided at 25 µL, 10mM.
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1,7-Heptanediolは、E3ユビキチンリガーゼリガンドと標的タンパク質リガンドを連結するPROTACリンカーとして機能する[1-2]。1,7-Heptanediolは医薬品中間体、疾患の治療、PROTAC技術研究に使える[3-4]。
In vitro（体内）実験で、1,7-Heptanediol（20mg/mL）でCT26、4T1、SMMC-7721とNCI-H1299細胞を1時間処理し、1,7-Heptanediolは4T1細胞に対して著しい細胞毒性を示した。4T1細胞を1,7-Heptanediol（1–5mg/mL）で24時間処理したところ、著しい毒性を示した。4T1細胞を1,7-Heptanediolリポソーム（脂質濃度は4 µg/mL）で24時間処理した。1,7-Heptanediolは、ミトコンドリア膜電位を低下させ、細胞のアポトーシスを促進した。12時間の処理後、1,7-Heptanediolは、細胞上清でATPのレベルを著しく上昇させ、免疫原性細胞死を誘発した[5]。
| 細胞実験 [1]: | |
|
細胞株 |
4T1細胞（マウス乳癌細胞株） |
|
調製方法 |
37°C、5% CO₂で、10% (v/v)ウシ胎児血清（FBS）と1% (v/v)ペニシリン-ストレプトマイシン-グルタミン（PS）を含有するRPMI 1640培地で4T1細胞を培養した。細胞を1,7-Heptanediol（1-20mg/mL）で処理した。 |
|
反応条件 |
1-20mg/mL；1または24時間 |
|
応用 |
1,7-Heptanediolは、4T1細胞に対する強力な細胞毒性を示した。 |
| Cas No. | 629-30-1 | SDF | |
| Formula | C7H16O2 | M.Wt | 132.20 |
| 溶解度 | Storage | Store at 2-8°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 7.5643 mL | 37.8215 mL | 75.643 mL |
| 5 mM | 1.5129 mL | 7.5643 mL | 15.1286 mL |
| 10 mM | 756.4 μL | 3.7821 mL | 7.5643 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A liquid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)