1,7-Heptanediol |
Catalog No.GD14338
One-Click Copy Product Info
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1,7-Heptanediol serves as a PROTAC linker for connecting E3 ubiquitin ligase ligands and target protein ligands.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 629-30-1
Sample solution is provided at 25 µL, 10mM.
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1,7-Heptanediol serves as a PROTAC linker for connecting E3 ubiquitin ligase ligands and target protein ligands[1-2]. 1,7-Heptanediol can be used in pharmaceutical intermediates, disease treatment, and PROTAC technology research[3-4].
In vitro, 1,7-Heptanediol (20mg/mL) was used to treat CT26, 4T1, SMMC-7721, and NCI-H1299 cells for 1 hour, 1,7-Heptanediol exhibited significant cytotoxicity against 4T1 cells. Treatment of 4T1 cells with 1,7-Heptanediol (1–5mg/mL) for 24 hours showed marked toxicity. 4T1 cells were treated with 1,7-Heptanediol liposomes (with a lipid concentration of 4 µg/mL) for 24 hours. 1,7-Heptanediol caused a decrease in mitochondrial membrane potential and promoted cell apoptosis. After a 12-hour treatment, 1,7-Heptanediol significantly increased ATP levels in the cell supernatant and induced immunogenic cell death[5].
References:
[1] De Paoli G, Bell S. A rapid GC-MS determination of gamma-hydroxybutyrate in saliva. J Anal Toxicol. 2008 May;32(4):298-302.
[2] Paborji M, Waugh WN, Stella VJ. Mechanistic investigation of the degradation of sulfamic acid 1,7-heptanediyl ester, an experimental cytotoxic agent, in water and 18oxygen-enriched water. J Pharm Sci. 1987 Feb;76(2):161-5.
[3] Özeren HD, Capezza AJ, Gharbi S, et al. Starch/Alkane Diol Materials: Unexpected Ultraporous Surfaces, Near-Isoporous Cores, and Films Moving on Water. ACS Omega. 2020 Oct 30;5(44):28863-28869
[4] Vinogradov SV, Suzdaltseva Y, Alakhov VYu, et al. Inhibition of herpes simplex virus 1 reproduction with hydrophobized antisense oligonucleotides. Biochem Biophys Res Commun. 1994 Sep 15;203(2):959-66.
[5] Gu M, Yu W, Stefanello ST, et al. Synergistic in vivo anticancer effects of 1,7-heptanediol and doxorubicin co-loadedliposomes in highly aggressive breast cancer. J Control Release. 2025 Jan 10;377:174-185.
| Cell experiment [1]: | |
Cell lines | 4T1 cells (mouse breast cancer cell line) |
Preparation Method | 4T1 cells were cultured in RPMI 1640 medium containing 10% (v/v) fetal bovine serum (FBS) and 1% (v/v) Penicillin-Streptomycin-Glutamine (PS) at 37°C, 5% CO₂. Cells were treated 1,7-Heptanediol (1-20mg/mL). |
Reaction Conditions | 1-20mg/mL; 1 or 24 hour. |
Applications | 1,7-Heptanediol showed potent cytotoxicity against 4T1 cells. |
References: | |
| Cas No. | 629-30-1 | SDF | |
| Formula | C7H16O2 | M.Wt | 132.20 |
| Solubility | Storage | Store at 2-8°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 7.5643 mL | 37.8215 mL | 75.643 mL |
| 5 mM | 1.5129 mL | 7.5643 mL | 15.1286 mL |
| 10 mM | 756.4 μL | 3.7821 mL | 7.5643 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A liquid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)