IDFP (Synonyms: Isopropyl Dodecylfluorophosphonate) |
カタログ番号GC43891 |
内因性カンナビノイドである2-アラキドノイルグリセロール(2-AG)とアラキドノイルエタノールアミド(AEA)は、中枢カンナビノイド受容体(CB1)および末梢カンナビノイド受容体(CB2)を活性化することによって、神経学的および代謝機能を調節する生物学的に活性の高い脂質です。
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Cas No.: 615250-02-7
Sample solution is provided at 25 µL, 10mM.
The endocannabinoids, 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA), are biologically active lipids that regulate diverse neurological and metabolic functions by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) hydrolyze 2-AG and AEA, respectively, thus terminating their biological function. IDFP is an organophosphorus compound that dually inhibits MAGL and FAAH with IC50 values of 0.8 and 3 nM, respectively. At 10 mg/kg, IDFP elevates brain levels of 2-AG and AEA more than 10-fold, and decreases levels of arachidonic acid by a similar magnitude.
Average Rating: 5
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