IMM-H007 |
カタログ番号GC25521 |
IMM-H007は、アデノシン誘導体であり、AMP-活性化プロテインキナーゼ(AMPK)の活性化剤です。IMM-H007は心機能障害の治療薬として有望です。IMM-H007はNF-κBおよびJNK/AP1シグナルを不活性化することにより内皮炎症を負に制御します。また、マクロファージにおいてABCA1(ATP結合カセットサブファミリーAメンバー1)の分解を抑制し、細胞表面局在化を促進するためコレステロール排出を促進します。
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Cas No.: 1221412-23-2
Sample solution is provided at 25 µL, 10mM.
IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.
IMM-H007 reduces isoprenaline-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent.[4]
[1] Weipeng Ge, et al. Eur J Pharmacol. 2019 Aug 15;857:172442. [2] Jinjin Yu, et al. Toxicol Appl Pharmacol. 2019 Oct 15;381:114732. [3] LinZhang Huang, et al. J Lipid Res. 2015 May;56(5):986-97.
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