Ingliforib (CP 368296) (Synonyms: CP 368296; GPi 296) |
| カタログ番号GC32658 |
Ingliforib (CP 368296) (CP 368296) はグリコーゲン ホスホリラーゼ阻害剤であり、肝臓、筋肉、脳のグリコーゲン ホスホリラーゼに対する IC50 は 52、352、150 nM で、心保護作用があります。
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Cas No.: 186392-65-4
Sample solution is provided at 25 µL, 10mM.
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Ingliforib is a glycogen phosphorylase inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.
Ingliforib is a glycogen phosphorylase inhibitor, and inhibits the myocardial GP isoforms (muscle and brain) with IC50s of 352 and 150 nM, respectively, also a potent inhibitor of the liver isoform (IC50 of 52 nM). Ingliforib (0.1, 1, 10 μM) dose-dependently reduces infarct size in the isolated rabbit hearts[1].
Ingliforib (15 mg/kg) potently reduces infarct size by 52%, and decreases plasma glucose and lactate concentrations in openchest anesthetized rabbits. Ingliforib (15 mg/kg) also inhibits myocardial glycogen phosphorylase a (GPa) and total glycogen phosphorylase (GP) activity in anesthetized rabbits[1].
[1]. Tracey WR, et al. Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor. Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1177-84.
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