Isodeoxycholic Acid (Synonyms: isoDCA) |
| カタログ番号GC47464 |
胆汁酸
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 566-17-6
Sample solution is provided at 25 µL, 10mM.
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Isodeoxycholic acid is a bile acid that is formed via epimerization of deoxycholic acid by intestinal bacteria.1 It has a greater critical micelle concentration than DCA, indicating reduced detergent activity, and is less active than DCA in inhibiting growth in a panel of seven gut commensal bacteria species. Isodeoxycholic acid (0.1%) inhibits spore germination induced by taurocholic acid in several C. difficile strains, as well as decreases the cytotoxicity of C. difficile culture supernatants to Vero cells.2 Plasma levels of isodeoxycholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.3
1.Devlin, A.S., and Fischbach, M.A.A biosynthetic pathway for a prominent class of microbiota-derived bile acidsNat. Chem. Biol.11(9)685-690(2018) 2.Thanissery, R., Winston, J.A., and Theriot, C.M.Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acidsAnaerobe4586-100(2017) 3.Lin, H., An, Y., Tang, H., et al.Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat modelJ. Agric. Food Chem.67(13)3624-3632(2019)
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