JMV3002 |
| カタログ番号GC43929 |
グレリンは、成長ホルモン分泌促進受容体の内因性リガンドであり、食欲を刺激し、エネルギー代謝を制御する視床下部調節核に信号を伝達します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 925239-03-8
Sample solution is provided at 25 µL, 10mM.
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Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. At 80 µg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 µg/kg.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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