KRpep-2d |
| カタログ番号GC64447 |
KRpep-2d は強力な K-Ras 阻害剤であり、K-Ras が駆動するがん細胞の増殖を阻害します。 KRpep-2d はがん研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2098181-84-9
Sample solution is provided at 25 µL, 10mM.
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KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1].
KRpep-2d has cyclic structure with importance for K-Ras inhibitory activity. Leu77 , Ile9 and Asp12 are critical amino acid residues for the K-Ras inhibitory activity of KRpep-2d[1]. KRpep-2d (10-30 μM) has inhibitory activity of A427 cells with the proliferation rates of 68.3% (10 μM) and 48.3% (10 μM)[1].
[1]. Niida A, et al. Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761.
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