Levomilnacipran (hydrochloride) (Synonyms: (1S-cis)-Milnacipran) |
| カタログ番号GC44057 |
ミルナシプラン (1S-cis) 塩酸塩は、線維筋痛症の臨床治療に使用されるセロトニン-ノルエピネフリン再取り込み阻害剤 (SNRI) です。
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Cas No.: 175131-60-9
Sample solution is provided at 25 µL, 10mM.
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Levomilnacipran is an active enantiomer of the serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor milnacipran . It binds to the 5-HT and NE transporters (Kis = 11.2 and 92.2 nM, respectively, for human recombinant transporters) and inhibits reuptake in vitro (IC50s = 19 and 10.5 nM, respectively). It is selective for 5-HT and NE transporters over DAT (Ki = >10,000 nM for human recombinant DAT) and 23 receptors (Kis = ≥10,000 nM). Levomilnacipran increases extracellular levels of 5-HT and NE in rat cortex with minimal effective doses (MEDs) of 20 and 10 mg/kg, respectively. It decreases immobility in the forced swim and tail suspension tests (MEDs = 20 and 2.5 mg/kg, respectively) without increasing locomotor activity. Formulations containing levomilnacipran have been used in the treatment of major depressive disorder.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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