Linoleoyl Glycine (Synonyms: Glycine Linoleamide, LinGly, NLinoleoyl Glycine) |
| カタログ番号GC44074 |
リノレオイルグリシンは修飾された多価不飽和脂肪酸です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2764/3/6
Sample solution is provided at 25 µL, 10mM.
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Arachidonyl glycine, the conjugate of arachidonic acid and glycine produced in mammalian brain, skin, and spinal cord, is a structural analog of anandamide (AEA) that is reported to have analgesic activities in whole animal experiments. It has poor affinity for the central cannabinoid (CB1) receptor, high-affinity for the G protein-coupled receptor GPR-18, and is metabolically regulated by fatty acid amide hydrolase (FAAH) activity. LinGly is an endogenous homolog of linoleoyl ethanolamide, an arachidonyl glycine. It inhibits the hydrolysis of AEA in FAAH-containing N18TG2 cell membranes with an IC50 value of ~25 µM, which is less potent than that of arachidonyl glycine (IC50 = 7 µM). The biological significance of LinGly has not yet been determined.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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