Lotilaner |
| カタログ番号GC65292 |
Lotilaner は寄生虫駆除剤であり、キイロショウジョウバエ GABA 受容体に対する 23.84 nM の IC50 で、昆虫 GABACl 受容体の強力な非競合的アンタゴニストとして機能します。
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Cas No.: 1369852-71-0
Sample solution is provided at 25 µL, 10mM.
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Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor[1].
Lotilaner shows IC50s of 38.25 ± 3.75, 52.40 ± 4.54, 36.79 ± 4.39 nM for Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2), Lepeophtheirus salmonis (Ls) and Rhipicephalus microplus (Rm) GABACl receptors, respectively[1].
[1]. Lotilaner, et al. The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls). Parasit Vectors. 2017 Nov 1;10(1):530.
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