LY2183240 2'-isomer |
| カタログ番号GC41181 |
LY2183240は、アナンダミドの取り込み（IC50 = 270 pM; Ki = 540 pM）および加水分解を競合的に阻害する強力な小分子阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1010096-65-7
Sample solution is provided at 25 µL, 10mM.
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LY2183240 is a potent, competitive small molecule inhibitor of anandamide uptake (IC50 = 270 pM; Ki = 540 pM) and hydrolysis. It has been shown to increase anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-dependent efficacy (3-30 mg/kg) in several rodent models of persistent pain. LY2183240 2'-isomer is a less potent, 2,5-regioisomer of LY2183240 that inhibits anandamide hydrolysis and uptake with IC50 values of 33 and 998 nM, respectively.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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