Methyl 1-Boc-azetidine-3-carboxylate |
| カタログ番号GC64158 |
1-Boc-アゼチジン-3-カルボン酸メチルは、抗体薬物複合体（ADC）の合成に使用される非切断型 ADC リンカーです。 1-Boc-アゼチジン-3-カルボン酸メチルも、PROTACの合成に使用できるアルキル鎖ベースのPROTACリンカーです[1
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 610791-05-4
Sample solution is provided at 25 µL, 10mM.
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Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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