ML-031 (Synonyms: CID-2113511) |
カタログ番号GC11668
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ML-031 は、IC50 と EC50 が 1.0 と 1.03 の強力で選択的なアゴニスト、スフィンゴシン 1-リン酸受容体 2 (S1PR2) です。 ML-031 は、がん疾患の研究に可能性を秘めています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 852230-33-2
Sample solution is provided at 25 µL, 10mM.
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ML-031 is an agonist of S1P2 with EC50 value of 1 μM [1].
Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation [1]. Sphingolipids belong to a family of bioactive molecules with cell signaling properties. Sphingosine 1-phosphate (S1P) is widely expressed on various tissues and cell types. S1P is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets [1]. Until now, five sphingosine-1-phosphate receptors (S1PR1-S1PR5) have been identified. S1PR4 and S1PR5 are prominently expressed in the immune and nervous systems, respectively. S1P functions by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.
ML-031 activated S1P2 with an EC50 value of 1 μM in a S1P reporter assay [1].
Reference:
[1] Satsu H, Schaeffer M T, Guerrero M, et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist[J]. Bioorganic & medicinal chemistry, 2013, 21(17): 5373-5382.
| Cas No. | 852230-33-2 | SDF | |
| 同義語 | CID-2113511 | ||
| Chemical Name | 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-2,5-pyrrolidinedione | ||
| Canonical SMILES | CC1=CC(C(CN2C(CCC2=O)=O)=O)=C(C)N1CC3=CC=CC=C3 | ||
| Formula | C19H20N2O3 | M.Wt | 324.4 |
| 溶解度 | ≤5mg/ml in ethanol;5mg/ml in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.0826 mL | 15.4131 mL | 30.8261 mL |
| 5 mM | 616.5 μL | 3.0826 mL | 6.1652 mL |
| 10 mM | 308.3 μL | 1.5413 mL | 3.0826 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)