ML-031 (Synonyms: CID-2113511) |
| カタログ番号GC11668 |
ML-031 は、IC50 と EC50 が 1.0 と 1.03 の強力で選択的なアゴニスト、スフィンゴシン 1-リン酸受容体 2 (S1PR2) です。 ML-031 は、がん疾患の研究に可能性を秘めています。
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Cas No.: 852230-33-2
Sample solution is provided at 25 µL, 10mM.
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ML-031 is an agonist of S1P2 with EC50 value of 1 μM [1].
Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation [1]. Sphingolipids belong to a family of bioactive molecules with cell signaling properties. Sphingosine 1-phosphate (S1P) is widely expressed on various tissues and cell types. S1P is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets [1]. Until now, five sphingosine-1-phosphate receptors (S1PR1-S1PR5) have been identified. S1PR4 and S1PR5 are prominently expressed in the immune and nervous systems, respectively. S1P functions by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.
ML-031 activated S1P2 with an EC50 value of 1 μM in a S1P reporter assay [1].
Reference:
[1] Satsu H, Schaeffer M T, Guerrero M, et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist[J]. Bioorganic & medicinal chemistry, 2013, 21(17): 5373-5382.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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