ML 277 (Synonyms: CID53347902) |
| カタログ番号GC10492 |
ML 277(CID53347902) は、EC50 が 270 nM の、新規で強力かつ選択的な K(v)7.1 (KCNQ1) カリウム チャネル活性化因子です。
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Cas No.: 1401242-74-7
Sample solution is provided at 25 µL, 10mM.
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ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.IC50 value: 270 nM (EC50) [1]Target: K(v)7.1 activatorML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel.
References:
[1]. Mattmann ME, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41.
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