MOG (35-55) (mouse, rat) (trifluoroacetate salt) (Synonyms: MEVGWYRSPFSRVVHLYRNGK, Myelin Oligodendrocyte Glycoprotein (35-55)) |
| カタログ番号GC52419 |
MOG抗原ペプチド
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Sample solution is provided at 25 µL, 10mM.
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Myelin oligodendrocyte glycoprotein (MOG) (35-55) is an antigen peptide of MOG, a protein involved in demyelinating CNS disorders.1,2 MOG (35-55) in combination with heat-killed M. tuberculosis and complete Freund's adjuvant (CFA) induces demyelination of the spinal cord, degeneration of the optic nerve, and visual impairments in mice.1 Immunization with MOG (35-55) in combination with adjuvants has been used to induce experimental autoimmune encephalomyelitis (EAE) in animal models of multiple sclerosis.1,2
1.Guo, X., Harada, C., Namekata, K., et al.Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient micePLoS One5(9)e13083(2010) 2.Zhang, F., Wei, W., Chai, H., et al.Aurintricarboxylic acid ameliorates experimental autoimmune encephalomyelitis by blocking chemokine-mediated pathogenic cell migration and infiltrationJ. Immunol.190(3)1017-1025(2013)
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