Moracin O |
| カタログ番号GC62406 |
Moracin O は、Mori Cortex Radicis から分離された 2-アリールベンゾフランです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 123702-97-6
Sample solution is provided at 25 µL, 10mM.
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Moracin O is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects[1][2][3].
Moracin O enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC50 value of 12.6 μM. Moracin O reduces ROS production in OGD-induced cell death (IC50 value of 0.3 μM). Moracin O protects neuronal cell death against the oxidative stress induced by OGD[1].
[1]. Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34(8):1373-80.
[2]. Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46(6):2386-96.
[3]. Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF?κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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