MRT-83 hydrochloride |
| カタログ番号GC63863 |
MRT-83 (塩酸塩) は、Smoothened (Smo) 受容体の強力なアンタゴニストです。 MRT-83 (塩酸塩) は、Hedgehog (Hh) シグナル伝達経路と BODIPY-シクロパミンのヒト Smo への結合を阻害します。 MRT-83 (塩酸塩) は、がん疾患の研究の可能性を秘めています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1359944-60-7
Sample solution is provided at 25 µL, 10mM.
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MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease[1].
MRT-83 (hydrochloride) (compound 86) has IC50s of 15 and 11 nM respectively in Shh-light2 and C3H10T1/2 cells in the biological activity assay[1].
[1]. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012;55(4):1559-1571.
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